What if we told you one of the Beta-Caryophyllene benefits might have something to do with Wolverine from X-Men?
But it may also help infuse your products with powerful soothing superpowers unlike any you’ve read about before.
Here’s why your brand cannot afford to leave out Beta-caryophyllene terpenes.
First, here’s a rundown of the hard science:
Beta-Caryophyllene is a chemical compound in the terpene family. Terpenes are common compounds found in plants that are responsible for distinct aromas and flavors in your favorite essential oils. Each one also produces specific health benefits. Chemical building blocks called isoprenes make up terpenes, and bicyclic sesquiterpenes like this one have three isoprene building block units.
We have Beta-Caryophyllene to thank for the spicy, peppery taste of black pepper and the woodsy smell of plants and oils like clove oil, copaifera oil, basil, hops, oregano, lavender, rosemary, and true cinnamon.
But these are the coolest facts about Beta-Caryophyllene:
People who research ways to make stronger cannabis with specific health benefits think terpenes like Beta-caryophyllene may also act together with cannabinoid chemicals in a process known as the entourage effect (1). This effect describes when two chemicals act together to produce a chemical effect stronger than either chemical alone.
Due to its smell, taste, and ability to act as a dietary cannabinoid, studies suggest you can use beta-caryophyllene as a flavoring agent or food additive, as well as in vape oils, cosmetics, creams, toothpaste, and other commercial products to enhance their therapeutic effects. (2)
Not sure what a dietary cannabinoid is?
Beta-Caryophyllene doesn't just contribute to the smell of cannabis.
See, your endocannabinoid system helps regulate various physiological and mental functions in your body. Two main cannabinoid receptors make this happen:
The CB1 and CB2 receptors.
While cannabinoids like THC are responsible for the psychoactive effects of cannabis when the compounds bind to CB1 receptors (that high feeling), this isn’t the case for Beta-caryophyllene. Doctors say Beta-caryophyllene acts as a dietary cannabinoid because it binds to CB2 receptors to help provide therapeutic benefits for conditions like inflammation, pain, and osteoporosis (2).
Here’s how Beta-caryophyllene can supercharge your products to provide your loyal customers with the benefits they’re looking for.
Scientists found beta-caryophyllene reduced inflammation in the brain and reduced chemicals that cause oxidative stress associated with inflammation (3). These anti-inflammatory properties may also help protect the brain from swelling and inflammation during a stroke to improve stroke outcome (4). Plus, you can help protect your gut, as treatment with beta-caryophyllene helped reduce gut inflammation in mouse models (5).
Your girlfriend doesn’t appreciate your dog breath or germ-covered hands. Luckily, studies suggest beta-caryophyllene helps fight bacterial dental plaque build-up(6). This makes it a potential naturally-derived alternative to typical medications like chlorhexidine that often require a prescription.
Plus, it helped reduce microorganisms like Streptococcus pneumonia, Haemophilus influenzae, and E. coli - each of which can cause nasty infections and illness (7).
Think happy thoughts... with some help from beta-caryophyllene! That’s what the research suggests, anyway, as mice treated with 50mg/kg of the terpene showed decreased numbers on tests measuring anxiety, depression, and compulsive activity (99). Harnessing this power for humankind offers exciting possibilities for natural alternatives to potentially addictive anxiolytics and antidepressants.
We’ve heard often enough about getting calcium and vitamin D to prevent diseases like osteoporosis that weaken the bones. But studies suggest β-caryophyllene may work as a therapeutic agent for the prevention and treatment of osteoporosis by increasing the building (mineralization) of stronger bones while decreasing their breakdown (adipogenesis and osteoclastogenesis)(8).
Ok, you’ve got us-we’re not saying you’ll end up with an adamantium skeleton like Wolverine (too bad, right?). But the results are promising for beta-caryophyllene as an ingredient to potentially help prevent reduced bone density.
Cancer, Alzheimer’s, and Multiple Sclerosis are some of the most confusing and frustrating conditions to suffer from.
Studies suggest beta-Caryophyllene reduces inflammation associated with multiple sclerosis and immune system dysfunction(9). It also shows potent anti-cancer properties, slowing cancer cell growth(10). Beta-Caryophyllene reduces the inflammatory and plaque buildup associated with the PPAR pathway in Alzheimer's disease(11).
Look out, chronic pain! Studies show this terpene may help provide reduce pain relating to the nervous system(12). Plus, beta-caryophyllene helps provide pain relief topically in creams and ointments because it acts as a local anesthetic(13). Finally, here’s some good news for those worried about opioid addiction:
Beta-caryophyllene may help relieve pain by releasing the same endorphins morphine does(14). This enhances the effects of morphine, potentially allowing for treatments using lower doses of the opioid.
How’s that for a final health benefit? Scientists tested Beta-Caryophyllene on a mouse model system made of worms and saw it increased the worms' lifespans by over 22%(15). The study suggests this terp reduces free radical levels, maintains cellular homeostasis, modulates feeding behavior, and regulates body size effectively to increase longevity.
The US Food and Drug Administration (FDA) considers Beta-Caryophyllene safe for consumption, even at high doses(16). Like many natural compounds, it may be a mild skin irritant if used improperly or for those who are allergic or have sensitive skin. Follow the instructions and you’re good to go.
Due to its action as a CB2 agonist, Beta-Caryophyllene shows promise as a non-psychoactive therapeutic compound that may:
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